About the Seminar

A/Prof Walker will discuss the role of TDP-43 pathology formation in MND, and advances in understanding of how TDP-43 dysfunction leads to neurodegeneration. Drawing on findings from cell, neuron, mouse and human studies, results highlighting new proteins involved in protection against TDP-43 pathology and biochemical pathways involved in disease pathogenesis will be discussed. Overall, this presentation will bring together current knowledge on possible avenues to therapies that may modulate TDP-43 pathology and highlight gaps in knowledge requiring further study. 

About the speaker

Adam Walker is Associate Professor and Group Leader in the Clem Jones Centre for Ageing Dementia Research at the Queensland Brain Institute of The University of Queensland. He is a Bill Guest FightMND Mid-Career Research Fellow and the Ross Maclean Fellow for MND Research, and is Head of the Neurodegeneration Pathobiology Laboratory. His research focuses on the key aggregating protein TDP-43 in MND, including identification of new genes and proteins that regulate TDP-43 pathology formation. The Walker lab employs advanced cell biology and biochemistry approaches alongside pre-clinical and proof-of-concept studies in mouse models of disease, to understand the molecular drivers of MND and to test potential new therapeutics. 

Future Seminars

• Nov 26, 2024 – Dr Sicong Tu